How Do You Spell CHOLESTERIN CLEFT?

1. A cholesterin cleft refers to a specific histopathological finding observed in some medical conditions, particularly in atherosclerosis and granulomatous inflammation. It represents the accumulation of cholesterol crystals within a cleft-like space.

   Cholesterol is a lipid molecule that plays a crucial role in various biological processes, but its excessive or abnormal deposition can lead to pathological conditions. In atherosclerosis, for example, the walls of arteries become progressively narrowed due to the buildup of cholesterol and other substances, forming plaques. Within these plaques, a cholesterin cleft can be observed.

   The cholesterin cleft is formed when cholesterol crystals, derived from lipids present in the plaque, precipitate and accumulate within a localized space. These crystals usually appear as needle-shaped structures, often surrounded by inflammatory cells and debris. The presence of a cholesterin cleft signifies ongoing pathological processes and is often considered a marker of disease progression.

   In granulomatous inflammation, which can be seen in conditions like tuberculosis or sarcoidosis, a similar histopathological feature can be observed. Cholesterol crystals can accumulate within granulomas, forming cholesterin clefts. This finding may aid in the diagnosis of these conditions but should be interpreted within the context of the clinical presentation and other supporting evidence.

   In summary, a cholesterin cleft is a histopathological finding characterized by the presence of cholesterol crystals within a cleft-like space. It is commonly observed in atherosclerosis and granulomatous inflammation and indicates ongoing pathological processes.

2. See under cleft.

   A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.

Common Misspellings for CHOLESTERIN CLEFT

The word "cholesterin cleft" is composed of two parts: "cholesterin" and "cleft".

1. Cholesterin: The term "cholesterin" comes from the German word "Cholesterin", which was derived from the Greek word "chole", meaning "bile", and the Greek word "steros", meaning "solid" or "stiff". It was first introduced in the mid-18th century by French chemist François Poulletier de la Salle to describe a solid, waxy substance found in gallstones.

2. Cleft: The word "cleft" originates from the Old English word "cloef", which means "split" or "cleave". It can be traced back to the Proto-Germanic word "kleuban", meaning "to cleave" or "to split".